Neighborhood disadvantage is associated with working memory and hippocampal volumes among older adults.
Regina S WrightAlexa C AllanAlyssa A GamaldoAdrienne A MorganAnna K LeeGuray ErusChristos DavatzikosDesirée C BygravePublished in: Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition (2024)
It is not well understood how neighborhood disadvantage is associated with specific domains of cognitive function and underlying brain health within older adults. Thus, the objective was to examine associations between neighborhood disadvantage, brain health, and cognitive performance, and examine whether associations were more pronounced among women. The study included 136 older adults who underwent cognitive testing and MRI. Neighborhood disadvantage was characterized using the Area Deprivation Index (ADI). Descriptive statistics, bivariate correlations, and multiple regressions were run. Multiple regressions, adjusted for age, sex, education, and depression, showed that higher ADI state rankings (greater disadvantage) were associated with poorer working memory performance ( p < .01) and lower hippocampal volumes ( p < .01), but not total, frontal, and white matter lesion volumes, nor visual and verbal memory performance. There were no significant sex interactions. Findings suggest that greater neighborhood disadvantage may play a role in working memory and underlying brain structure.
Keyphrases
- working memory
- white matter
- physical activity
- healthcare
- transcranial direct current stimulation
- cerebral ischemia
- attention deficit hyperactivity disorder
- resting state
- public health
- multiple sclerosis
- mental health
- functional connectivity
- magnetic resonance imaging
- sleep quality
- depressive symptoms
- risk assessment
- quality improvement
- magnetic resonance
- cross sectional
- computed tomography
- metabolic syndrome
- blood brain barrier
- polycystic ovary syndrome
- contrast enhanced
- adipose tissue
- skeletal muscle
- social media