Integration of miRNA-regulatory networks in hepatic stellate cells identifies TIMP3 as a key factor in chronic liver disease.

Fida AzarKevin CourtetBassil DekkyDominique BonnierOlivier DameronAlain ColigeVincent LegagneuxNathalie Théret

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Several miRNAs targeting TIMP3 are up-regulated in activated HSCs and down-regulation of TIMP3 expression is associated with inflammatory activity in liver fibrosis and poor prognosis in HCC. The regulatory network including specific miRNAs and TIMP3 is therefore central for the evolution of chronic liver disease.

Keyphrases

poor prognosis
liver fibrosis
long non coding rna
transcription factor
induced apoptosis
cell cycle arrest
genome wide
gene expression
drug induced
signaling pathway
cell death
dna methylation
binding protein
network analysis