The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia.

Yu-Sheng ChengHsing-Yi ChenYu-Chiao LinYi-Syuan LinYi-Chun YehYi-Hsuan YehYung-Hsuan ChengYung-Ming LinHan-Yu WengTsung-Yen LinShih-Chieh Lin

Published in: Andrology (2023)

We highlight prominent MAEL expression in the intratesticular spermatid and the mitochondria of ejaculated spermatozoa. MAEL directly binds to GPX4 and UBL4B, and loss of MAEL induces mitochondrial dysfunction. MAEL-mitochondrial function-motility relationship might advance our understanding of the causes of asthenozoospermia.

Keyphrases

poor prognosis
endothelial cells
cell death
reactive oxygen species
endoplasmic reticulum
long non coding rna
escherichia coli
biofilm formation
pseudomonas aeruginosa
cystic fibrosis