Metabolomics and Biochemical Benefits of Multivitamin and Multimineral Supplementation in Healthy Individuals: A Pilot Study.
María Carmen SánchezAna HerráizMaría J CiudadMarta AriasRaquel AlonsoCarmen DoblasArancha Llama-PalaciosLuis ColladoPublished in: Foods (Basel, Switzerland) (2024)
Scientific evidence regarding the effectiveness of vitamin and mineral supplements in healthy individuals remains scarce. In a randomized, double-blind study, 30 healthy individuals were assigned to receive a single daily dose of multivitamin and multimineral supplementation or a double daily dose for 30 days. Before and after the intake, an untargeted metabolomics assay for serum metabolites was conducted by hydrophilic interaction liquid chromatography-mass spectrometry, and clinical assessments of peripheral blood samples were performed. A paired t -test for metabolic analysis, adjusted using the false discovery rate (FDR) and p -value correction method (rate of change > 2 and FDR < 0.05), the Shapiro-Wilk test, Student's t -test, and the Mann-Whitney U test were applied depending on the variable, with a 5% significance level. An impact on oxidative stress was observed, with a significant reduction in homocysteine levels and an increment of pyridoxic acid (vitamin B6). The effect on energy metabolism was shown by a significant increase in diverse metabolites, such as linoleoylcarnitine. Serum iron and calcium levels were also impacted. Overall, we observed a nutritional balance compatible with a good state of health. In conclusion, beneficial effects on adult health were demonstrated in relation to oxidative stress, energy metabolism, and nutritional balance.
Keyphrases
- mass spectrometry
- liquid chromatography
- oxidative stress
- high resolution mass spectrometry
- tandem mass spectrometry
- peripheral blood
- healthcare
- high performance liquid chromatography
- public health
- gas chromatography
- capillary electrophoresis
- mental health
- randomized controlled trial
- clinical trial
- solid phase extraction
- simultaneous determination
- double blind
- high throughput
- induced apoptosis
- ischemia reperfusion injury
- high resolution
- health information
- systematic review
- small molecule
- climate change
- heat stress
- young adults
- heat shock
- gas chromatography mass spectrometry
- signaling pathway
- weight gain