Protective Effect of Combined Caffeic Acid Phenethyl Ester and Bevacizumab Against Hydrogen Peroxide-Induced Oxidative Stress in Human RPE Cells.

Published in: Current eye research (2017)

CAPE has a protective effect on ARPE-19 cells against oxidative stress, and VEGF protein level and expression can be decreased by incubation with different concentrations of CAPE. These results demonstrate that CAPE suppresses the mitochondria-mediated apoptosis in ARPE-19 cells under oxidative stress. In addition, the use of CAPE in combination with bevacizumab has an additive effect.

Keyphrases

induced apoptosis
south africa
hydrogen peroxide
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
endothelial cells
signaling pathway
cell death
dna damage
poor prognosis
reactive oxygen species
vascular endothelial growth factor
heat stress