TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells.
Mao YangXiaobin YuXuesen LiBo LuoWenli YangYan LinDabing LiZhonglin GanJianming XuTao HePublished in: Breast cancer research : BCR (2018)
Activation of iFGFR1 promotes ERK1/2 activity, EMT, cell proliferation, tumor growth, DCIS progression to invasive cancer, and altered the gene expression profile of DCIS-iFGFR1 cells. Activation of iFGFR1 upregulated TNFAIP3 in an ERK2-dependent manner and TNFAIP3 is required for iFGFR1 activation-promoted DCIS.COM cell proliferation, mammosphere growth, tumor growth and progression. These results suggest that TNFAIP3 may be a potential target for inhibiting DCIS growth and progression promoted by FGFR1 signaling.
Keyphrases
- cell proliferation
- signaling pathway
- pi k akt
- induced apoptosis
- endothelial cells
- cell cycle
- cell cycle arrest
- squamous cell carcinoma
- genome wide
- gene expression
- risk assessment
- dna methylation
- oxidative stress
- transcription factor
- pluripotent stem cells
- human health
- squamous cell
- induced pluripotent stem cells
- childhood cancer