Small molecule inhibitor of TLR4 inhibits ovarian cancer cell proliferation: new insight into the anticancer effect of TAK-242 (Resatorvid).
Bahareh KashaniZahra ZandiDavood BashashAzam ZaghalMajid MomenyEnsieh M PoursaniAtieh Pourbagheri-SigaroodiSeyed A MousaviSeyed H GhaffariPublished in: Cancer chemotherapy and pharmacology (2019)
TAK-242 serves as an appealing therapeutic strategy in the TLR4-expressing OC cells, either in the context of monotherapy or in combination with a chemotherapeutic drug.
Keyphrases
- small molecule
- toll like receptor
- cell proliferation
- inflammatory response
- induced apoptosis
- immune response
- cell cycle arrest
- cell cycle
- protein protein
- combination therapy
- endoplasmic reticulum stress
- randomized controlled trial
- open label
- signaling pathway
- oxidative stress
- emergency department
- cell death
- adverse drug
- wild type