A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues.
Alessandra MancaAmedeo De NicolòElisa Delia De VivoMicol FerraraSharon OhSahar KhaliliNiamh HigginsRobert G DeissStefano BonoraJessica CusatoAlice PalermitiJacopo MulaSara GianellaAntonio D'AvolioPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
Results in terms of linearity, accuracy, precision, recovery and matrix effect fitted the recommendations of FDA and EMA guidelines, and the sensitivity was high enough to allow successful application on human autoptic specimens from an ethically approved clinical study, confirming its eligibility for post-mortem pharmacological/toxicological studies.