Effects of Liraglutide on Heart Rate and Heart Rate Variability: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.
Preman KumarathuraiChristian AnholmBjørn S LarsenRasmus Huan OlsenSten MadsbadOle KristiansenOlav W NielsenSteen B HaugaardAhmad SajadiehPublished in: Diabetes care (2016)
In overweight patients with CAD and newly diagnosed T2D, liraglutide increased HR and reduced HRV despite significant weight loss and improvement in metabolic parameters. The increase in nightly HR in conjunction with a decrease in parameters of parasympathetic activity suggests that liraglutide may affect sympathovagal balance.
Keyphrases
- heart rate variability
- heart rate
- placebo controlled
- weight loss
- double blind
- newly diagnosed
- blood pressure
- bariatric surgery
- clinical trial
- phase ii
- roux en y gastric bypass
- study protocol
- phase iii
- coronary artery disease
- gastric bypass
- weight gain
- physical activity
- phase ii study
- type diabetes
- randomized controlled trial
- metabolic syndrome
- adipose tissue
- squamous cell carcinoma
- skeletal muscle
- rectal cancer
- open label
- locally advanced