Free Fatty Acid Increases the Expression of NLRP3-Caspase1 in Adipose Tissue Macrophages in Obese Severe Acute Pancreatitis.

Tao XuLiping ShengXianwen GuoChaoqun Han

Published in: Digestive diseases and sciences (2021)

Inflammation increases in adipose tissue macrophages of obese mice with severe acute pancreatitis. Free fatty acid generated via adipocyte lipolysis worsens inflammation in adipose tissue macrophages and the outcome of severe acute pancreatitis in obese mice through the NLRP3-caspase1 inflammasome pathway.

Keyphrases

adipose tissue
fatty acid
insulin resistance
high fat diet
oxidative stress
early onset
cell death
induced apoptosis
drug induced
metabolic syndrome
type diabetes
nlrp inflammasome
bariatric surgery
binding protein
skeletal muscle
signaling pathway
long non coding rna