Rare Germline ATM Variants Influence the Development of Chronic Lymphocytic Leukemia.

Benjamin L Lampson Aditi Gupta Svitlana Tyekucheva Kiyomi MashimaAnna PetráčkováZixu WangNatalia WojciechowskaConner J ShaughnessyPeter O BakerStacey M FernandesSamantha Shupe John-Hanson MachadoRayan FardounAnnette S KimJennifer R Brown

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)

p.L2307F) have functional significance and should not be ignored. Further studies are needed to determine whether these variants affect the response to therapy or account for some of the inherited risk of CLL.

Keyphrases

chronic lymphocytic leukemia
copy number
dna repair
dna damage
dna damage response
case control
gene expression
stem cells
dna methylation
oxidative stress
mesenchymal stem cells
cell therapy