Circadian-Coupled Genes Expression and Regulation in HIV-Associated Chronic Obstructive Pulmonary Disease (COPD) and Lung Comorbidities.
Kingshuk PandaSrinivasan ChinnapaiyanMd Sohanur RahmanMaria J SantiagoStephen M BlackHoshang J UnwallaPublished in: International journal of molecular sciences (2023)
People living with HIV (PLWH) have an elevated risk of chronic obstructive pulmonary disease (COPD) and are at a higher risk of asthma and worse outcomes. Even though the combination of antiretroviral therapy (cART) has significantly improved the life expectancy of HIV-infected patients, it still shows a higher incidence of COPD in patients as young as 40 years old. Circadian rhythms are endogenous 24 h oscillations that regulate physiological processes, including immune responses. Additionally, they play a significant role in health and diseases by regulating viral replication and its corresponding immune responses. Circadian genes play an essential role in lung pathology, especially in PLWH. The dysregulation of core clock and clock output genes plays an important role in chronic inflammation and aberrant peripheral circadian rhythmicity, particularly in PLWH. In this review, we explained the mechanism underlying circadian clock dysregulation in HIV and its effects on the development and progression of COPD. Furthermore, we discussed potential therapeutic approaches to reset the peripheral molecular clocks and mitigate airway inflammation.
Keyphrases
- chronic obstructive pulmonary disease
- antiretroviral therapy
- hiv infected patients
- lung function
- hiv infected
- hiv positive
- human immunodeficiency virus
- immune response
- hiv aids
- genome wide
- healthcare
- hepatitis c virus
- ejection fraction
- men who have sex with men
- poor prognosis
- newly diagnosed
- prognostic factors
- cystic fibrosis
- bioinformatics analysis
- air pollution
- genome wide identification
- mental health
- dendritic cells
- south africa
- working memory
- patient reported outcomes
- single molecule
- insulin resistance
- oxidative stress
- gene expression
- risk factors
- toll like receptor
- long non coding rna