A 42-year-old male patient with high-risk prostate adenocarcinoma underwent baseline 99m Tc-methylene diphosphonate skeletal scintigraphy, which revealed two skeletal metastases and an area of faint radiotracer uptake in the left femoral shaft. In view of oligo-metastatic nature of the disease in the bone scan and the young age of the patient, he was a candidate for metastases-directed treatment. Single photon emission computed tomography (SPECT)/CT was performed to further characterize this lesion. It was revealed to be a small soft tissue density lesion within the fatty bone marrow density, suggesting bone marrow involvement. A more sensitive evaluation of such areas with faint radiotracer uptake may be needed in high-risk prostate cancer patients where access to advanced modalities is limited. Their significance will also need reassessment as their detection will improve with technological advancements.
Keyphrases
- bone marrow
- computed tomography
- squamous cell carcinoma
- benign prostatic hyperplasia
- soft tissue
- prostate cancer
- dual energy
- positron emission tomography
- case report
- small cell lung cancer
- mesenchymal stem cells
- pet imaging
- image quality
- pet ct
- magnetic resonance imaging
- contrast enhanced
- single cell
- locally advanced
- radical prostatectomy
- middle aged
- loop mediated isothermal amplification
- radiation therapy
- bone regeneration
- real time pcr
- label free
- fatty acid
- smoking cessation
- combination therapy
- sensitive detection