Determinants of fibrotic atrial cardiomyopathy in atrial fibrillation. A multicenter observational study of the RETAC (reseau européen de traîtement d'arrhythmies cardiaques)-group.
Björn Mueller-EdenbornZoraida Moreno-WeidmannSandrine VenierPascale DefayeChan-Il ParkJosé GuerraConcepcion Alonso-MartínVictor BazanXavier VinolasEnrique Rodriguez-FontBieito Campos GarciaSerge BovedaStéphane CombesJean-Paul AlbenqueBenoit Guy-MoyatDietmar TrenkMartin EichenlaubJuan ChenHeiko LehrmannFranz-Josef NeumannThomas ArentzAmir JadidiPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2021)
Age, sex and AF-phenotype are the main determinants for the development of FAM. A low AF-SCORE ≤ 2 is found in paroxysmal AF-patients of any age and younger patients with persistent AF irrespective of sex, and associated with favorable outcomes of PVI-only. Freedom from arrhythmia remains unsatisfactory with AF-SCORE ≥ 3 as found in older patients, particularly females, with persistent AF, and future studies investigating adjunctive atrial ablations to PVI-only should focus on these groups of patients.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- end stage renal disease
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- percutaneous coronary intervention
- clinical trial
- skeletal muscle
- type diabetes
- patient reported outcomes
- left ventricular
- weight loss
- idiopathic pulmonary fibrosis
- cross sectional