Cell-specific characterization of the placental methylome.

Victor YuanDesmond HuiYifan YinMaria S PeñaherreraAlexander G BeristainWendy P Robinson

Published in: BMC genomics (2021)

Our results provide a comprehensive analysis of DNAm in human placental cell types from first trimester and term pregnancies. This data will serve as a useful DNAm reference for future placental studies, and we provide access to this data via download from GEO (GSE159526), through interactive exploration from the web browser ( https://robinsonlab.shinyapps.io/Placental_Methylome_Browser/ ), and through the R package planet, which allows estimation of cell composition directly from placental DNAm data.

Keyphrases

single cell
cell therapy
electronic health record
big data
endothelial cells
stem cells
pregnant women
mesenchymal stem cells
gestational age
preterm birth
data analysis
artificial intelligence
pluripotent stem cells
induced pluripotent stem cells