The BDNF Val66Met Polymorphism is a Relevant, But not Determinant, Risk Factor in the Etiology of Neuropsychiatric Disorders - Current Advances in Human Studies: A Systematic Review.

Published in: Brain plasticity (Amsterdam, Netherlands) (2022)

Compilation of experimental findings reveals that the Val66Met polymorphism affects BDNF function by slightly altering the processing, distribution, and regulated release of BDNF. Regarding the critical role of pro-BDNF as a pro-apoptotic factor, such alteration might represent a risk for the development of neuropsychiatric disorders.

Keyphrases

stress induced
anti inflammatory
endothelial cells
risk factors
tyrosine kinase
case control
pluripotent stem cells