Atrial fibrillation burden: an update-the need for a CHA2DS2-VASc-AFBurden score.
Kathryn D TiverJing QuahAnandaroop LahiriAnand N GanesanAndrew D McGaviganPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021)
Atrial fibrillation (AF) is an established independent risk factor for stroke. Current guidelines regard AF as binary; either present or absent, with the decision for anti-coagulation driven by clinical variables alone. However, there are increasing data to support a biological gradient of AF burden and stroke risk, both in clinical and non-clinical AF phenotypes. As such, this raises the concept of combining AF burden assessment with a clinical risk score to refine and individualize the assessment of stroke risk in AF-the CHA2DS2VASc-AFBurden score. We review the published data supporting a biological gradient to try and construct a putative schema of risk attributable to AF burden.
Keyphrases
- atrial fibrillation
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- direct oral anticoagulants
- heart failure
- percutaneous coronary intervention
- big data
- risk factors
- randomized controlled trial
- systematic review
- machine learning
- venous thromboembolism
- coronary artery disease
- blood brain barrier
- data analysis
- deep learning
- decision making
- clinical practice