Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile.
Brian SkaugZsuzsanna H McMahanWilliam R SwindellMonique E HinchcliffTracy M FrechVirginia D SteenFaye N HantJessica K GordonAmi A ShahLisha ZhuW Jim ZhengJeffrey L BrowningAlexander M S BarronMinghua WuSudha VisvanathanPatrick BaumJennifer M FranksMichael L WhitfieldVictoria K ShanmugamRobyn T DomsicFlavia V CastelinoElana J BernsteinNancy WareingMarka A LyonsJun YingJulio CharlesMaureen D MayesShervin AssassiPublished in: Annals of the rheumatic diseases (2019)
Skin in early diffuse SSc has prominent innate and adaptive immune cell signatures. As a prominently affected end organ, these signatures reflect the preceding rate of disease progression. These findings could have implications in understanding SSc pathogenesis and clinical trial design.