5-aza-2'-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human uterine leiomyomas.

María Cristina Carbajo-GarcíaAna CorachánMarina Segura-BenitezJavier MonleónJulia EscrigAmparo FausAntonio PellicerIrene CervellóHortensia Ferrero

Published in: Reproductive biology and endocrinology : RB&E (2021)

5-aza-CdR treatment inhibits cell proliferation, ECM formation, and Wnt/β-catenin signaling pathway targets in HULP cells, suggesting that DNA methylation inhibition is a viable therapeutic target in uterine leiomyoma.

Keyphrases

cell death
cell proliferation
extracellular matrix
cell cycle arrest
dna methylation
cell cycle
pi k akt
endothelial cells
induced apoptosis
stem cells
genome wide
pluripotent stem cells
copy number
signaling pathway
combination therapy