Joint testing of overall and simple effects for the two-by-two factorial trial design.
Eric S LeiferJames F TroendleAlexis KoleckiDean A FollmannPublished in: Clinical trials (London, England) (2021)
When there is no interaction, Equal Allocation 3 has less power than a factorial analysis. However, Equal Allocation 3 often has greater power when there is an interaction. The R package factorial2x2 can be used to explore the power gain or loss for different scenarios.