Carrier protein mediated cargo sensing in quorum signal synthases.
Patrick D FischerAbu Sayeed ChowdhuryThomas BartholowShibani BasuEric BaggsHuel S CoxSrđan MatošinMichael D BurkartLisa WarnerRajesh NagarajanHaribabu ArthanariPublished in: Chemical communications (Cambridge, England) (2023)
Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein-enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.