Diminished DEFA6 Expression in Paneth Cells Is Associated with Necrotizing Enterocolitis.

Laszlo MarkaszAlkwin WandersLaszlo SzekelyHelene Engstrand Lilja

Published in: Gastroenterology research and practice (2018)

The diminished DEFA6 expression in Paneth cells associated with NEC in this study supports the hypothesis that alpha-defensins are involved in the pathophysiology of NEC. Future studies are needed to elucidate the role of alpha-defensins in NEC aiming at finding preventive and therapeutic strategies against NEC.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
oxidative stress
binding protein
long non coding rna
current status