Towards an ultra-rapid smartphone- connected test for infectious diseases.
Valérian TurbéEleanor R GrayVictoria E LawsonEleni NastouliJennifer C BrookesRobin A WeissDeenan PillayVincent C EmeryC Theo VerripsHiromi YatsudaDale AtheyRachel A McKendryPublished in: Scientific reports (2017)
The development is reported of an ultra-rapid, point-of-care diagnostic device which harnesses surface acoustic wave (SAW) biochips, to detect HIV in a finger prick of blood within 10 seconds (sample-in-result-out). The disposable quartz biochip, based on microelectronic components found in every consumer smartphone, is extremely fast because no complex labelling, amplification or wash steps are needed. A pocket-sized control box reads out the SAW signal and displays results electronically. High analytical sensitivity and specificity are found with model and real patient blood samples. The findings presented here open up the potential of consumer electronics to cut lengthy test waiting times, giving patients on the spot access to potentially life-saving treatment and supporting more timely public health interventions to prevent disease transmission.
Keyphrases
- public health
- infectious diseases
- end stage renal disease
- newly diagnosed
- ejection fraction
- high resolution
- chronic kidney disease
- health information
- hiv infected
- hepatitis c virus
- hiv positive
- case report
- physical activity
- healthcare
- transcription factor
- prognostic factors
- peritoneal dialysis
- patient reported outcomes
- hiv aids
- loop mediated isothermal amplification
- risk assessment
- patient reported
- quantum dots
- climate change
- combination therapy
- human health
- global health
- replacement therapy
- smoking cessation