Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT Negative Isolated Mild Traumatic Brain Injury.
Jonathan ReyesGershon SpitzBrendan P MajorWilliam T O'BrienLauren P GieslerJesse W BainBecca XieJeffrey V RosenfeldMeng LawJennie Louise PonsfordTerence J O'BrienSandy ShultzCatherine WillmottBiswadev MitraStuart J McDonaldPublished in: Neurology (2023)
These findings indicate that adding IL-6 to a panel of brain-specific proteins such as GFAP and UCH-L1 might assist in the acute diagnosis of mTBI in adults under 50. Multiple markers had high classification accuracy in participants without LOC/PTA. When compared with the best performing acute markers, sub-acute measures of plasma NfL resulted in minimal reduction in classification accuracy. Future studies will investigate the optimal time frame over which plasma IL-6 might assist diagnostic decisions and how extracranial trauma affects utility.
Keyphrases
- liver failure
- respiratory failure
- mild traumatic brain injury
- drug induced
- aortic dissection
- machine learning
- deep learning
- hepatitis b virus
- computed tomography
- intensive care unit
- multiple sclerosis
- extracorporeal membrane oxygenation
- internal carotid artery
- acute respiratory distress syndrome
- middle cerebral artery