Oncologic outcomes of human papillomavirus-associated oropharynx carcinoma treated with surgery alone: A 12-institution study of 344 patients.

William R RyanMary J XuEdgar OchoaKarolina A Plonowska-HirschfeldAaron L ZebolskyPatrick K HaArnaud F BewleyJonathan Mallen-St ClairArjun S JoshiCharles S CoffeyFarhoud FarajiBridget V MacDonaldJeffrey J HoultonTheodore A GobillotJoseph M CurryRamez PhilipsTrevor G HackmanJeremy D RichmonAndrew J HolcombAndrew M CoughlinAru PanwarRussell B SmithMatthew E HerbergCarole A FakhryDavid M Cognetti

Published in: Cancer (2021)

With careful selection, surgery alone for AJCC 7th pT0-T2N0-N2b HPV+OPSCC with zero to 3 pathologic LNs without perineural invasion, extranodal extension, or positive margins results in high DFS, DSS, OS, and salvage treatment success. Because of the short-term follow-up, these data support further investigation of treatment de-escalation in this population.

Keyphrases

minimally invasive
coronary artery bypass
randomized controlled trial
prostate cancer
electronic health record
lymph node
squamous cell carcinoma
skeletal muscle
high grade
surgical site infection
atrial fibrillation
big data
robot assisted
radical prostatectomy
acute coronary syndrome
replacement therapy