Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases.

Wing-Hong Jonathan HoAndrew M K LawEtienne Masle-FarquharLesley E CastilloAmanda MawsonBrendan J Houston Christopher C Goodnow David Gallego Ortega Samantha Richelle Oakes Christopher J Ormandy

Published in: Breast cancer research : BCR (2022)

These data establish OAS2 as a therapeutic target for agents designed to reduce metastases and increase the effectiveness of checkpoint immunotherapy.

Keyphrases

papillary thyroid
dna damage
randomized controlled trial
sars cov
systematic review
squamous cell
cell cycle
electronic health record
preterm birth
big data
mouse model
pregnancy outcomes
squamous cell carcinoma
pregnant women
data analysis