Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis.

Rodrigo Coutinho de AlmeidaMargo TuerlingsYolande RamosWouter Den HollanderEka SuchimanNico LakenbergRob G H H NelissenHailiang MeiIngrid Meulenbelt

Published in: Rheumatology (Oxford, England) (2022)

By prioritizing proxy transcript SNPs that mark AEI in cartilage and/or subchondral bone at loci harboring GWAS signals, we present an unbiased approach to identify the most likely functional OA risk-SNP and gene. We identified 10 new potential OA risk genes ready for further, translation towards underlying biological mechanisms.

Keyphrases

genome wide
genome wide association
dna methylation
knee osteoarthritis
bone mineral density
copy number
poor prognosis
rheumatoid arthritis
bone loss
gene expression
bone regeneration
rna seq
climate change
genome wide analysis
extracellular matrix
breast cancer risk