Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus.

Shuaihantian LuoRuifang WuQianwen LiGuiying Zhang

Published in: Journal of immunology research (2022)

TET2 recruited by STAT3 induces DNA demethylation of IFI44L promoter which promotes IFI44L overexpression in monocyte contributing to the pathogenesis of SLE by enhancing the maturation and functions of Mo-DC. IFI44L is expected to become a new target for treatment of SLE.

Keyphrases

dendritic cells
systemic lupus erythematosus
regulatory t cells
immune response
cell proliferation
disease activity
poor prognosis
transcription factor
dna methylation
gene expression
rheumatoid arthritis
cell free
single molecule
endothelial cells
long non coding rna
smoking cessation
circulating tumor cells