A Preliminary Randomized Controlled Trial of Different Treatment Regimens for Melancholic Depression.

Yun WangXiaohua LiuDai-Hui PengYan WuYun-Ai SuJia XuXiancang MaYi LiJianfei ShiXiaojing ChengHan RongYi-Ru Fang

Published in: Neuropsychiatric disease and treatment (2021)

This preliminary trial suggests that all four interventions (fluoxetine, fluoxetine+CBT, fluoxetine+bupropion, and fluoxetine+bupropion+brain stimulation) achieved similar response and remission rates in patients with melancholic depression, but that fluoxetine had a better effect on self-consciousness than fluoxetine+bupropion. The safety profile was manageable.

Keyphrases

randomized controlled trial
study protocol
depressive symptoms
white matter
systematic review
systemic lupus erythematosus
disease activity
brain injury
ulcerative colitis
open label
functional connectivity