A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer.
Claire Emily FletcherL DengF OrafidiyaW YuanM P G S LorentzenO W CyranA Varela-CarverT A ConstantinD A LeachF M DobbsI FigueiredoB GurelE ParkesD BogdanR R PereiraS G ZhaoA NeebF IssaJ HesterH KudoY LiuY PhilippouR BristowK KnudsenR J BryantF Y FengS H ReedI G MillsJ de BonoCharlotte Lynne BevanPublished in: Molecular cancer (2022)
A balancing act between miR-346 and NORAD regulates DNA damage and repair in PC. miR-346 may be particularly effective as a therapeutic in the context of decreased NORAD observed in advanced PC, and in transcriptionally-hyperactive cancer cells.