IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice.

Jiyeon OckJun-Kyu SuhSoon-Sun HongJu-Hee KangGuo Nan Yin Ji Kan Ryu

Published in: Andrology (2022)

Knockdown of IGFBP5 improved erectile function in diabetic mice by promoting cell proliferation and reducing apoptosis and permeability. Local inhibition of IGFBP5 expression may provide a new treatment strategy for diabetic ED and other ischemic vascular or neurological diseases.

Keyphrases

cell proliferation
endothelial cells
emergency department
poor prognosis
oxidative stress
type diabetes
endoplasmic reticulum stress
nucleic acid
cell death
benign prostatic hyperplasia
cell cycle
cell cycle arrest
ischemia reperfusion injury
pi k akt