Neutrophil activation identifies patients with active polyarticular gout.
Daisy VedderM GerritsenB DuvvuriR F van VollenhovenM T NurmohamedC LoodPublished in: Arthritis research & therapy (2020)
Neutrophil activation markers are associated with characteristics of active, polyarticular gout. Furthermore, NETs are present in the peripheral blood of gout patients. However, NETs do not associate with markers of disease activity or inflammation. Future research should point out if peroxidase and calprotectin could be used in clinical practice as biomarkers for monitoring gout disease activity.
Keyphrases
- disease activity
- juvenile idiopathic arthritis
- systemic lupus erythematosus
- rheumatoid arthritis
- uric acid
- rheumatoid arthritis patients
- ankylosing spondylitis
- peripheral blood
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- oxidative stress
- peritoneal dialysis
- current status
- hydrogen peroxide
- prognostic factors
- nitric oxide
- patient reported