Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.

Yan LinBin BaoHao YinXin WangAirong FengLin ZhaoXianqi NieNan YangGuo-Ping ShiJian Liu

Published in: BMC biology (2019)

This study reveals a previously undescribed molecular mechanism by which peripheral CPL-1/cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin signaling.

Keyphrases

high fat diet induced
adipose tissue
fatty acid
chemotherapy induced
insulin resistance
wild type
skeletal muscle