Protocol of a randomised phase III clinical trial of sequential capecitabine or 5-fluorouracil plus bevacizumab (Cape/5-FU-Bmab) to capecitabine or 5-fluorouracil plus oxaliplatin plus bevacizumab (CapeOX/mFOLFOX6-Bmab) versus combination CapeOX/mFOLFOX6-Bmab in advanced colorectal cancer: the C-cubed (C3) study.

Takeshi NagasakaHideyuki MishimaAkira SawakiMototsugu ShimokawaMichio InukaiKatsunori ShinozakiHiroaki TaniokaJunichiro NasuTomohiro NishinaShoichi HazamaMasazumi OkajimaYoshiyuki Yamaguchi

Published in: BMJ open (2016)

UMIN000015405, Pre-results.

Keyphrases

phase iii
metastatic colorectal cancer
clinical trial
open label
phase ii study
double blind
placebo controlled
phase ii
south africa
study protocol
randomized controlled trial
squamous cell carcinoma
locally advanced
radiation therapy
rectal cancer