Macrophages and Bone Remodeling.
Megan M WeivodaElizabeth W BradleyPublished in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2023)
Bone remodeling in the adult skeleton facilitates the removal and replacement of damaged and old bone to maintain bone quality. Tight coordination of bone resorption and bone formation during remodeling crucially maintains skeletal mass. Increasing evidence suggests that many cell types beyond osteoclasts and osteoblasts support bone remodeling, including macrophages and other myeloid lineage cells. Herein, we discuss the origin and functions for macrophages in the bone microenvironment, tissue resident macrophages, osteomacs, as well as newly identified osteomorphs that result from osteoclast fission. We also touch on the role of macrophages during inflammatory bone resorption. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Keyphrases
- bone loss
- bone mineral density
- soft tissue
- bone regeneration
- postmenopausal women
- body composition
- randomized controlled trial
- single cell
- induced apoptosis
- systematic review
- oxidative stress
- bone marrow
- immune response
- signaling pathway
- cell proliferation
- cell death
- blood brain barrier
- quality improvement
- cell cycle arrest
- cell fate