Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism.
Isabel Espinosa-SalinasGonzalo ColmenarejoCristina M Fernández-DíazMarta Gómez de CedrónJ Alfredo MartinezGuillermo RegleroAna Ramírez de MolinaPublished in: Scientific reports (2022)
The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public health emergency. Increasing understanding about predisposing factors to infection and severity is now a priority. Genetic, metabolic, and environmental factors can play a crucial role in the course and clinical outcome of COVID-19. We aimed to investigate the putative relationship between genetic factors associated to obesity, metabolism and lifestyle, and the presence and severity of SARS-CoV-2 infection. A total of 249 volunteers (178 women and 71 men, with mean and ± SD age of 49 ± 11 years) characterized for dietary, lifestyle habits and anthropometry, were studied for presence and severity of COVID-19 infection, and genotyped for 26 genetic variants related to obesity, lipid profile, inflammation, and biorhythm patterns. A statistically significant association was found concerning a protective effect of APOE rs7412 against SARS-CoV-2 infection (p = 0.039; OR 0.216; CI 0.084, 0.557) after correction for multiple comparisons. This protective effect was also ascribed to the APOɛ2 allele (p = 0.001; OR 0.207; CI 0.0796, 0.538). The genetic variant rs7412 resulting in ApoE2, genetic determinant of lipid and lipoprotein levels, could play a significant role protecting against SARS-CoV-2 infection.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- public health
- metabolic syndrome
- coronavirus disease
- weight loss
- genome wide
- insulin resistance
- cognitive decline
- high fat diet
- type diabetes
- copy number
- cardiovascular disease
- emergency department
- oxidative stress
- weight gain
- healthcare
- high fat diet induced
- adipose tissue
- gene expression
- skeletal muscle
- polycystic ovary syndrome
- risk factors
- global health