NLRP3 (rs10754558) gene polymorphism and tumor necrosis factor alpha as predictors for disease activity and response to methotrexate and adalimumab in psoriasis.

Fatma Z KamelHeba Allah Mohamed HoseinyAya A El ShahawyGhada BoghdadiAlia A El Shahawy

Published in: BMC immunology (2024)

The NLRP3 (rs10754558) genotypes GC was associated with the severe form of psoriasis and with nonresponse to psoriasis medication. Therefore, NLRP3 (rs10754558) gene polymorphism is an important prognostic biomarker in psoriasis patients. The serum TNFα can be used as a predictor for response to therapy in psoriasis patients. More research for evaluation of role of the NLRP3 gene polymorphism in the genetic risks and treatment outcomes associated with psoriasis is still required.

Keyphrases

rheumatoid arthritis
end stage renal disease
disease activity
chronic kidney disease
ejection fraction
newly diagnosed
systemic lupus erythematosus
peritoneal dialysis
prognostic factors
stem cells
healthcare
nlrp inflammasome
high dose
rheumatoid arthritis patients
high resolution
bone marrow
smoking cessation