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Investigation of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions and performance of a rapid diagnostic test for identifying asymptomatic malaria infection in northern Ethiopia, 2015.

Colleen M LeonardAshenafi AssefaJessica N McCafferyCamelia HermanMateusz PlucinskiHeven SimeHussein MohammedAmha KebedeHiwot SolomonMebrahtom HaileMatt MurphyJimee HwangEric Rogier
Published in: Malaria journal (2022)
There is evidence of dual pfhrp2/3 gene deletions in the Tigray and Amhara regions of Ethiopia in 2015. As the prevalence of malaria was very low (<ā€‰2%), it is difficult to make strong conclusions on RDT performance, but these results challenge the utility of biomarkers in household surveys in very low transmission settings.
Keyphrases
  • plasmodium falciparum
  • copy number
  • genome wide
  • genome wide identification
  • risk factors
  • cross sectional
  • dna methylation
  • gene expression
  • loop mediated isothermal amplification
  • genome wide analysis