Staphylococcus aureus -Derived Extracellular Vesicles Enhance the Efficacy of Endocrine Therapy in Breast Cancer Cells.
Jeongshin AnHyungju KwonWoosung LimByung-In MoonPublished in: Journal of clinical medicine (2022)
The microbiome involved in the human estrogen metabolism is known as the estrobolome. This study aimed to show that the estrobolome can be used in breast cancer treatment. We first analyzed the blood microbiome composition of healthy controls and patients with breast cancer. In particular, we investigated the bacteria producing β-glucuronidase and/or β-galactosidase, which are involved in estrogen metabolism in the human body. Staphylococcus species were more abundant in healthy controls than in breast cancer patients and therefore were selected for further analyses. The effect of Staphylococcus aureus on endocrine therapy was analyzed by a combination treatment with tamoxifen. Analysis of the microbiome of blood samples showed that species producing β-glucuronidase were more abundant in breast cancer patients than in healthy controls. Further experiments confirmed that the efficacy of tamoxifen increased when administered in conjugation with the extracellular vesicles (EVs) of S. aureus . Based on our results, we deduced that S. aureus EVs could potentially be used as adjuvants for breast cancer treatment in the future.
Keyphrases
- staphylococcus aureus
- breast cancer cells
- estrogen receptor
- endothelial cells
- biofilm formation
- induced pluripotent stem cells
- pluripotent stem cells
- methicillin resistant staphylococcus aureus
- positive breast cancer
- stem cells
- escherichia coli
- pseudomonas aeruginosa
- cell therapy
- high resolution
- genetic diversity
- bone marrow
- candida albicans