Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress.
Daolin JiWangyang ZhengPeng HuangYue YaoXiangyu ZhongPengcheng KangZhidong WangGuojing ShiYi XuYunfu CuiPublished in: OncoTargets and therapy (2020)
Huaier could inhibit cell proliferation, invasion and metastasis by modulating the expression of TP73-AS1, meanwhile promote apoptosis of CCA cells through disturbing mitochondrial function, inducing oxidative stress and activating caspases in vitro. In addition, Huaier could suppress tumor growth and metastasis by regulating the expression of proliferation and EMT-related proteins. In the meantime, Huaier prolonged the survival of nude mice in lung metastatic model with acceptable drug safety.
Keyphrases
- oxidative stress
- induced apoptosis
- signaling pathway
- cell cycle arrest
- poor prognosis
- pi k akt
- cell proliferation
- endoplasmic reticulum stress
- epithelial mesenchymal transition
- dna damage
- diabetic rats
- small cell lung cancer
- ischemia reperfusion injury
- squamous cell carcinoma
- cell death
- binding protein
- cell cycle
- adipose tissue
- type diabetes