Targeted inhibition of PPARα ameliorates CLA-induced hypercholesterolemia via hepatic cholesterol biosynthesis reprogramming.

Hao-Yu LiuPing HuYanwei LiMing-An SunHuan QuQiufang ZongHaotian GuXiaobo ChenWenbin BaoDemin Cai

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

Our study unravels that the small-molecule compound GW6471 exerts an attractive therapeutic effect for CLA-induced HCL, involving multiple pathways with the "PPARα-RORγ-SREBP2" being a potential complex player in this hepatic cholesterol biosynthesis programming.

Keyphrases

small molecule
high glucose
diabetic rats
low density lipoprotein
insulin resistance
drug induced
type diabetes
oxidative stress
cardiovascular disease
adipose tissue
fatty acid
endothelial cells
mouse model
drug delivery
metabolic syndrome
coronary artery disease
climate change
cardiovascular events
stress induced