LncRNA XIST modulates miR-328-3p ectopic expression in lung injury induced by tobacco-specific lung carcinogen NNK both in vitro and in vivo.

Bingxin LiXuezheng LiZhe JiangDi ZhouYuan FengGang ChenNing Li

Published in: British journal of pharmacology (2024)

Our results highlight the promotive effect of lncRNA XIST in NNK-induced lung injury and elucidate its post-transcriptional mechanisms, indicating that targeting lncRNA XIST/miR-328-3p could be a potential therapeutic strategy to prevent tobacco carcinogen-induced lung injury in vivo.

Keyphrases

high glucose
long non coding rna
diabetic rats
poor prognosis
gene expression
transcription factor
cancer therapy
oxidative stress
binding protein
drug delivery
heat shock