The protease-inhibitor SerpinB3 as a critical modulator of the stem-like subset in human cholangiocarcinoma.
Margherita CorrentiAndrea CapponMirella PastoreBenedetta PiombantiGiulia LoriDouglas V P N OliveiraPatricia Munoz-GarridoMonika LewinskaJesper B AndersenCédric CoulouarnLaurent SulpiceCaterina Peraldo NeiaGiuliana CavalloniSantina QuartaAlessandra BiasioloMatteo FassanMatteo RamazzottiMatteo ParriStefania RecalcatiLuca di TommasoClaudia CampaniInvernizzi PietroGuido TorzilliFabio MarraPatrizia PontissoChiara RaggiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2021)
These findings indicate a SB3 role in mediating malignant phenotype of CCA and identify a new therapeutic target.