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Claudin-1 is linked to presence of implants and micropapillary pattern in serous borderline epithelial tumours of the ovary.

Ahmed El-BalatIryna SchmeilKhayal GasimliNicole SängerThomas KarnAndre AhrSven BeckerRuza ArsenicUwe HoltrichKnut Engels
Published in: Journal of clinical pathology (2018)
In conclusion, Claudin-1 expression is associated with the presence of peritoneal implants and micropapillary pattern, which have been shown to be associated with poor prognosis. We speculate that overexpression of Claudin-1 might be linked to the mitogen-activated protein kinase pathway activation in BOT and suggest further studies to define its prognostic and potential therapeutic value.
Keyphrases
  • poor prognosis
  • long non coding rna
  • high grade
  • soft tissue
  • cell proliferation
  • transcription factor
  • tyrosine kinase
  • protein kinase