GCM2 Silencing in Parathyroid Adenoma Is Associated With Promoter Hypermethylation and Gain of Methylation on Histone 3.

Priyanka SinghSanjay Kumar BhadadaDivya DahiyaUma Nahar SaikiaAshutosh Kumar AryaNaresh SachdevaJyotdeep KaurArunanshu BeheraMaria Luisa BrandiSudhaker Dhanwada Rao

Published in: The Journal of clinical endocrinology and metabolism (2021)

These findings suggest the concurrent association of promoter hypermethylation and higher H3K9me3 with the repression of GCM2 expression in parathyroid adenomas. Treatment with DAC restored GCM2 expression in PTH-C1 cells. Our results showed a possible epigenetic landscape in the tumorigenesis of parathyroid adenoma and also that DAC may be a promising avenue of research for parathyroid adenoma therapeutics.

Keyphrases

dna methylation
poor prognosis
gene expression
genome wide
induced apoptosis
transcription factor
binding protein
small molecule
oxidative stress
single cell
radiation therapy
endoplasmic reticulum stress
locally advanced
replacement therapy