Spectrum of neuroimaging findings post-proton beam therapy in a large pediatric cohort.
Debarata BhattacharyaSahil ChhabdaRahul LakshmananRonald TanRichard WarneMassimo BenenatiAnthony MichalskiKristian AquilinaThomas JacquesDarren HargraveYen-Ching ChangJenny GainsKshitij MankadPublished in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)
In accordance with published literature, we found evidence of varied intracranial imaging changes in pediatric brain tumor patients treated with PBT. There was a higher incidence (10%) of large vessel cerebral arteriopathy in our cohort than previously described in the literature. Twenty-eight percent of patients had clinical sequelae as a result of these changes, particularly in the large vessel arteriopathy subgroup, arguing the need for angiographic and perfusion surveillance to pre-empt any morbidities and offer potential neuro-protection.
Keyphrases
- systematic review
- end stage renal disease
- ejection fraction
- newly diagnosed
- high resolution
- public health
- peritoneal dialysis
- risk factors
- stem cells
- randomized controlled trial
- subarachnoid hemorrhage
- computed tomography
- magnetic resonance imaging
- risk assessment
- clinical trial
- patient reported outcomes
- cell therapy
- mass spectrometry
- contrast enhanced
- blood brain barrier