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Spectrum of neuroimaging findings post-proton beam therapy in a large pediatric cohort.

Debarata BhattacharyaSahil ChhabdaRahul LakshmananRonald TanRichard WarneMassimo BenenatiAnthony MichalskiKristian AquilinaThomas JacquesDarren HargraveYen-Ching ChangJenny GainsKshitij Mankad
Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)
In accordance with published literature, we found evidence of varied intracranial imaging changes in pediatric brain tumor patients treated with PBT. There was a higher incidence (10%) of large vessel cerebral arteriopathy in our cohort than previously described in the literature. Twenty-eight percent of patients had clinical sequelae as a result of these changes, particularly in the large vessel arteriopathy subgroup, arguing the need for angiographic and perfusion surveillance to pre-empt any morbidities and offer potential neuro-protection.
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