Cognitive response to testosterone replacement added to intensive lifestyle intervention in older men with obesity and hypogonadism: prespecified secondary analyses of a randomized clinical trial.
Giulia GregoriAlessandra CelliYoann BarnouinArjun PaudyalReina Armamento-VillarealNicola NapoliClifford QuallsDennis T VillarealPublished in: The American journal of clinical nutrition (2021)
These findings suggest that in the high-risk population of older men with obesity and hypogonadism, testosterone replacement may improve cognitive function with lifestyle behaviors controlled via lifestyle intervention therapy.This trial was registered at clinicaltrials.gov as NCT02367105.
Keyphrases
- weight loss
- metabolic syndrome
- replacement therapy
- middle aged
- physical activity
- insulin resistance
- randomized controlled trial
- cardiovascular disease
- smoking cessation
- type diabetes
- community dwelling
- study protocol
- high fat diet induced
- weight gain
- clinical trial
- phase iii
- bone marrow
- stem cells
- adipose tissue
- mesenchymal stem cells
- phase ii
- skeletal muscle
- open label
- cell therapy
- double blind