Statin use and survival among women with ovarian cancer: an Australian national data-linkage study.
Jia-Li FengSuzanne C Dixon-SuenSusan J JordanPenelope M WebbPublished in: British journal of cancer (2021)
Use of statins may confer a survival benefit for women with ovarian cancer but it is impossible to rule out bias in observational studies. Particularly problematic are reverse causation where disease status affects statin use, confounding by indication and the absence of data for women with normal cholesterol levels. A randomised trial is required to provide definitive evidence.
Keyphrases
- cardiovascular disease
- low density lipoprotein
- electronic health record
- big data
- coronary artery disease
- free survival
- genome wide
- type diabetes
- quality improvement
- open label
- randomized controlled trial
- squamous cell carcinoma
- clinical trial
- locally advanced
- artificial intelligence
- high density
- hiv testing
- double blind