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Modeling allele-specific expression at the gene and SNP levels simultaneously by a Bayesian logistic mixed regression model.

Jing XieRocío Melissa RiveraMarco A R FerreiraYahan LiBhaumik N PatelRocio M Rivera
Published in: BMC bioinformatics (2019)
We will show that the proposed method exhibits improved control of the false discovery rate and improved power over existing methods when SNP variation and biological variation are present. Besides, our method also maintains low computational requirements that allows for whole genome analysis.
Keyphrases
  • genome wide
  • poor prognosis
  • dna methylation
  • small molecule
  • high density
  • copy number
  • high throughput
  • genetic diversity
  • gene expression
  • binding protein
  • transcription factor
  • single cell
  • data analysis