TRPA1: a molecular view.
Jannis E MeentsCosmin I CiotuMichael J M FischerPublished in: Journal of neurophysiology (2018)
The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues and has become a major target in the development of novel pharmaceuticals. A remarkable feature of the channel is its long list of activators, many of which we are exposed to in daily life. Many of these agonists induce pain and inflammation, making TRPA1 a major target for anti-inflammatory and analgesic therapies. Studies in human patients and in experimental animals have confirmed an important role for TRPA1 in a number of pain conditions. Over the recent years, much progress has been made in elucidating the molecular structure of TRPA1 and in discovering binding sites and modulatory sites of the channel. Because the list of published mutations and important molecular sites is steadily growing and because it has become difficult to see the forest for the trees, this review aims at summarizing the current knowledge about TRPA1, with a special focus on the molecular structure and the known binding or gating sites of the channel.
Keyphrases
- chronic pain
- neuropathic pain
- pain management
- anti inflammatory
- end stage renal disease
- chronic kidney disease
- oxidative stress
- healthcare
- spinal cord
- endothelial cells
- ejection fraction
- single molecule
- prognostic factors
- physical activity
- randomized controlled trial
- systematic review
- deep learning
- spinal cord injury
- induced pluripotent stem cells
- case control
- meta analyses